L-Dihydroorotic Acid
- CAS No.5988-19-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity L-Dihydroorotic Acid (CAS 5988-19-2), a key chiral intermediate in nucleotide and pyrimidine biosynthesis pathways for pharmaceutical R&D.
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Product Overview
L-Dihydroorotic Acid is a high-value chiral building block widely utilized in the synthesis of biologically active pyrimidine derivatives and nucleotide analogs. As a critical intermediate in the de novo pyrimidine biosynthesis pathway, it serves as a substrate for dihydroorotate dehydrogenase (DHODH), making it indispensable in metabolic studies and antiviral or anticancer drug development programs.
Specifications
| Molecular Formula | C₅H₆N₂O₄ |
|---|---|
| Molecular Weight | 158.11 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 254–255 °C (dec.) |
| Density | 1.523 g/cm³ |
| Specific Rotation | +33.3° (c=2, 1% NaHCO₃) |
| Purity (HPLC) | ≥99.9% |
| Enantiomeric Excess (ee) | ≥99.4% |
| Loss on Drying | ≤0.5% (0.15% typical) |
| Storage Conditions | Store at 0–5°C under inert atmosphere |
Industrial Applications
This compound is primarily employed as a specialized intermediate in the pharmaceutical industry for the synthesis of complex APIs targeting viral replication and cellular proliferation. Its high enantiomeric purity ensures reproducible stereochemical outcomes in multi-step syntheses. Additionally, L-Dihydroorotic Acid is used in biochemical assays to study mitochondrial enzyme kinetics and metabolic flux in cancer cell lines.
- Essential precursor in pyrimidine nucleotide biosynthesis
- High enantiopurity (>99.4% ee) ensures reliable chiral integrity
- Suitable for GMP-compliant early-stage API development
- Compatible with enzymatic and chemical transformation protocols
