Cholesteryl Hemisuccinate
- CAS No.1510-21-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Cholesteryl Hemisuccinate (CAS 1510-21-0), a key steroidal intermediate used in lipid-based drug delivery systems and advanced organic synthesis.
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Product Overview
Cholesteryl Hemisuccinate is a monoester derivative of cholesterol and succinic acid, widely employed as a critical building block in pharmaceutical and biotechnological research. With the molecular formula C31H50O4 and a molecular weight of 486.73 g/mol, this compound combines the amphiphilic properties of cholesterol with a carboxylic acid functionality, enabling its integration into liposomal formulations, micellar systems, and prodrug designs. Its structural versatility supports enhanced membrane stability and controlled release profiles in advanced drug delivery platforms.
Specifications
| Molecular Formula | C31H50O4 |
|---|---|
| Molecular Weight | 486.73 g/mol |
| Appearance | White powder |
| Melting Point | 178 °C |
| Density | 1.06 g/cm³ |
| Boiling Point | 586 °C at 760 mmHg |
| Flash Point | 179.6 °C |
| Refractive Index | -34° (c=2, CHCl3) |
| Vapor Pressure | 2.99E-15 mmHg at 25 °C |
| Assay (Purity) | ≥97.0% (Typical: 97.7%) |
Industrial Applications
As a specialty steroidal intermediate, Cholesteryl Hemisuccinate is primarily utilized in the development of lipid nanoparticles (LNPs), liposomes, and other colloidal carriers for therapeutic delivery. Its carboxylic acid group allows for facile conjugation to active pharmaceutical ingredients (APIs) or surface functionalization, making it invaluable in targeted drug delivery and diagnostic imaging agents. Additionally, it serves as a precursor in the synthesis of more complex steroidal architectures within medicinal chemistry pipelines.
- Enables stable liposomal bilayer formation due to cholesterol backbone
- Facilitates covalent modification via carboxyl group for tailored pharmacokinetics
- Complies with stringent quality standards for preclinical and early-phase clinical material sourcing
- Suitable for GMP-aligned manufacturing processes when required
